In 2002, as divinely intentioned, Dr Olapade Agoro became a politician under the mentorship and followership oof Dr. Bode Olajumoke, BL, Ph.D (now distinguished Senator of the Federal Republic of Nigeria).
This finally led to him charismatically and colourfully running the Presidential race in 2003 and 2007 against the best then in Nigeria; Chief Olusegun Obasanjo (GCFR), General Muhammadu Buhari (GCFR) and Chief Emeka Odumegwu Ojukwu, Ndigbo Gburugburu, the Ikemba of Nnewi now of blessed memory.
Olusegun Obasanjo and Muhammadu Buhari ended up becoming, at one time or the other, President, Commander-In-Chief of the Armed Forces Federal Republic of Nigeria.
In July 2006, he became the National Chairman, Conference of Nigeria Political Parties (CNPP).